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Crystal structure of the ligand binding domain of the ultraspiracle protein usp, the ortholog of rxrs in insects

Analyse Crystal structure of the ligand binding domain of the ultraspiracle protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1G2N
Type: protein
Length: 246 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ultraspiracle protein
UniProt: Q7SIF6
Ligands: EPH
Pockets: 3 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 64% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ultraspiracle protein	protein	246	64% helix, 4% strand	Q7SIF6

Ligands and binding sites

EPH · L-alpha-phosphatidyl-beta-oleoyl-gamma-palmitoyl-phosphatidylethanolamine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	516	0.83	0.89	35	EPH
2	266	0.56	0.77	26	empty
3	124	0.42	0.76	25	empty

Compared structures

1G2N · Crystal structure of the ligand binding domain of the ultraspiracle protein usp, the… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7SIF6
Elsewhere: RCSB PDB 1G2N · PDBe 1G2N · UniProt Q7SIF6

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