Research workbench
Human respiratory syncytial virus fusion protein core
Analyse Human respiratory syncytial virus fusion protein core in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1G2C
- Type
- protein
- Length
- 1,039 residues
- Chains
- 24
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein (F)
- UniProt
- P11209
- Pockets
- 8 · best druggability 0.82
Structure
x-ray diffraction · 12 distinct chains · 87% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, U, W | Fusion protein (F) | protein | 50 | 94% helix, 0% strand | P11209 |
| B | Fusion protein (F) | protein | 40 | 73% helix, 0% strand | P11209 |
| C, E | Fusion protein (F) | protein | 48 | 96% helix, 0% strand | P11209 |
| D, F, J | Fusion protein (F) | protein | 36 | 78% helix, 0% strand | P11209 |
| G, Q | Fusion protein (F) | protein | 49 | 94% helix, 0% strand | P11209 |
| H, N, P, R | Fusion protein (F) | protein | 37 | 78% helix, 0% strand | P11209 |
| I, S | Fusion protein (F) | protein | 50 | 88% helix, 0% strand | P11209 |
| K | Fusion protein (F) | protein | 48 | 92% helix, 0% strand | P11209 |
| L | Fusion protein (F) | protein | 40 | 73% helix, 0% strand | P11209 |
| M | Fusion protein (F) | protein | 47 | 91% helix, 0% strand | P11209 |
| O | Fusion protein (F) | protein | 50 | 96% helix, 0% strand | P11209 |
| T, V, X | Fusion protein (F) | protein | 38 | 82% helix, 0% strand | P11209 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 552 | 0.82 | 0.88 | 68 | empty |
| 2 | 363 | 0.77 | 0.87 | 55 | empty |
| 3 | 237 | 0.67 | 0.85 | 43 | empty |
| 4 | 73 | 0.61 | 0.90 | 22 | empty |
| 5 | 136 | 0.57 | 0.83 | 16 | empty |
Interfaces
62 interfaces between chains.
- W–X · 1051 Ų buried · 11 hydrogen bonds · protein-protein
- K–L · 1048 Ų buried · 10 hydrogen bonds · protein-protein
- S–T · 1023 Ų buried · 12 hydrogen bonds · protein-protein
- U–V · 1013 Ų buried · 6 hydrogen bonds · protein-protein
- Q–R · 1012 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1G2C · Human respiratory syncytial virus fusion protein core · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11209
- Elsewhere: RCSB PDB 1G2C · PDBe 1G2C · UniProt P11209
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