Research workbench
Crystal structure of aqpz H174G,T183F
Analyse Crystal structure of aqpz H174G,T183F in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3NKA
- Type
- protein
- Length
- 463 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aquaporin Z
- UniProt
- P60844
- Pockets
- 5 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aquaporin Z | protein | 230 | 75% helix, 0% strand | P60844 |
| B | Aquaporin Z | protein | 233 | 74% helix, 0% strand | P60844 |
Ligands and binding sites
- BOG · octyl beta-D-glucopyranoside · additive · 4 copies · chains A, B
- GOL · Glycerol · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.45 | 0.77 | 30 | empty |
| 2 | 114 | 0.45 | 0.78 | 23 | GOL |
| 3 | 118 | 0.42 | 0.76 | 26 | empty |
| 4 | 98 | 0.40 | 0.76 | 22 | GOL |
| 5 | 73 | 0.28 | 0.72 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 135 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P60844
- Elsewhere: RCSB PDB 3NKA · PDBe 3NKA · UniProt P60844
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.