Research workbench
Structure of the nosiheptide-resistance methyltransferase
Analyse Structure of the nosiheptide-resistance methyltransferase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3NK6
- Type
- protein
- Length
- 521 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 23S rRNA methyltransferase
- EC
- 2.1.1.-
- UniProt
- P52391
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 23S rRNA methyltransferase (EC 2.1.1.-) | protein | 264 | 39% helix, 20% strand | P52391 |
| B | 23S rRNA methyltransferase (EC 2.1.1.-) | protein | 257 | 39% helix, 21% strand | P52391 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 311 | 0.66 | 0.81 | 51 | empty |
| 2 | 111 | 0.64 | 0.89 | 23 | empty |
| 3 | 120 | 0.42 | 0.76 | 22 | empty |
| 4 | 120 | 0.42 | 0.76 | 21 | empty |
| 5 | 90 | 0.42 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1279 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3NK6 · Structure of the Nosiheptide-resistance methyltransferase · the same entry in another collection · chain B against B, TM-score 1.00
- P52391 · AlphaFold monomer V2.0 prediction for 23S rRNA (ADENOSINE(1067)-2'-O)-methyltransferase… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52391
- Elsewhere: RCSB PDB 3NK6 · PDBe 3NK6 · UniProt P52391
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