Research workbench
Crystal structure of extended dimerization module of RNA polymerase I subcomplex A49/A34.5
Analyse Crystal structure of extended dimerization module of RNA polymerase I… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3NFF
- Type
- protein
- Length
- 819 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase I subunit A49; RNA polymerase I subunit A34.5
- EC
- 2.7.7.6
- UniProt
- Q6FNZ9, Q6FQI3
- Pockets
- 7 · best druggability 0.84
Structure
x-ray diffraction · 4 distinct chains · 3% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase I subunit A49 (EC 2.7.7.6) | protein | 99 | 4% helix, 46% strand | Q6FNZ9 |
| B, D, F | RNA polymerase I subunit A34.5 (EC 2.7.7.6) | protein | 110 | 4% helix, 28% strand | Q6FQI3 |
| C, E, G | RNA polymerase I subunit A49 (EC 2.7.7.6) | protein | 93 | 4% helix, 48% strand | Q6FNZ9 |
| H | RNA polymerase I subunit A34.5 (EC 2.7.7.6) | protein | 111 | 0% helix, 32% strand | Q6FQI3 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 774 | 0.84 | 0.87 | 114 | empty |
| 2 | 1035 | 0.72 | 0.76 | 82 | empty |
| 3 | 200 | 0.55 | 0.79 | 29 | empty |
| 4 | 215 | 0.52 | 0.77 | 32 | empty |
| 5 | 163 | 0.42 | 0.74 | 22 | empty |
Interfaces
20 interfaces between chains.
- A–E · 2953 Ų buried · 51 hydrogen bonds · protein-protein
- C–G · 2909 Ų buried · 42 hydrogen bonds · protein-protein
- B–E · 1626 Ų buried · 23 hydrogen bonds · protein-protein
- D–G · 1612 Ų buried · 17 hydrogen bonds · protein-protein
- A–H · 1600 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3NFF · Crystal structure of extended Dimerization module of RNA polymerase I subcomplex A49/A34.5 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6FNZ9
- Every structure of UniProt Q6FQI3
- Elsewhere: RCSB PDB 3NFF · PDBe 3NFF · UniProt Q6FNZ9 · UniProt Q6FQI3
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