X-ray structure of a C-3'-methyltransferase in complex with S- adenosyl-L-homocysteine and sugar product

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 24% strand (DSSP).

Ligands and binding sites

• SAH · S-adenosyl-L-homocysteine · ligand · chains A
• JHZ · (2R,4S,6R)-4-amino-4,6-dimethyl-5-oxotetrahydro-2H-pyran-2-yl [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) · ligand · chains A
• ZN · Zinc ion · metal · chains A
• PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 3NDJ · X-ray Structure of a C-3'-Methyltransferase in Complex with S-Adenosyl-L-Homocysteine and… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt B5L6K6
• Elsewhere: RCSB PDB 3NDJ · PDBe 3NDJ · UniProt B5L6K6