Research workbench
Crystal structure of human RMI1C-RMI2 complex
Analyse Crystal structure of human RMI1C-RMI2 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3NBH
- Type
- protein
- Length
- 281 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Recq-mediated genome instability protein 1; Recq-mediated genome instability protein 2
- UniProt
- Q9H9A7, Q96E14
- Pockets
- 6 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Recq-mediated genome instability protein 1 | protein | 150 | 42% helix, 29% strand | Q9H9A7 |
| B | Recq-mediated genome instability protein 2 | protein | 131 | 20% helix, 43% strand | Q96E14 |
Pockets
6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 172 | 0.48 | 0.77 | 20 | empty |
| 2 | 83 | 0.40 | 0.78 | 14 | empty |
| 3 | 55 | 0.37 | 0.80 | 12 | empty |
| 4 | 73 | 0.36 | 0.76 | 15 | empty |
| 5 | 85 | 0.32 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1314 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 3NBH · Crystal structure of human RMI1C-RMI2 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q96E14 · AlphaFold monomer V2.0 prediction for recq-mediated genome instability protein 2 (Q96E14) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q9H9A7 · AlphaFold monomer V2.0 prediction for recq-mediated genome instability protein 1 (Q9H9A7) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H9A7
- Every structure of UniProt Q96E14
- Elsewhere: RCSB PDB 3NBH · PDBe 3NBH · UniProt Q9H9A7 · UniProt Q96E14
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