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Crystal structures and functional analysis of murine norovirus RNA- dependent RNA polymerase
Analyse Crystal structures and functional analysis of murine norovirus RNA- dependent… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3NAH
- Type
- protein
- Length
- 1,456 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA dependent RNA polymerase
- UniProt
- Q80J95
- Ligands
- SO4
- Pockets
- 20 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA dependent RNA polymerase | protein | 486 | 42% helix, 17% strand | Q80J95 |
| B, C | RNA dependent RNA polymerase | protein | 485 | 40% helix, 16% strand | Q80J95 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1060 | 0.72 | 0.76 | 108 | empty |
| 2 | 613 | 0.70 | 0.78 | 70 | empty |
| 3 | 463 | 0.65 | 0.78 | 51 | empty |
| 4 | 312 | 0.61 | 0.78 | 49 | empty |
| 5 | 304 | 0.55 | 0.75 | 44 | empty |
Interfaces
2 interfaces between chains.
- B–C · 1234 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 621 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3NAH · Crystal structures and functional analysis of murine norovirus RNA-dependent RNA… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q80J95
- Elsewhere: RCSB PDB 3NAH · PDBe 3NAH · UniProt Q80J95
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