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Structure of CSM1 full-length

Analyse Structure of CSM1 full-length in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3N4X
Type: protein
Length: 612 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Monopolin complex subunit CSM1
UniProt: P25651
Pockets: 7 · best druggability 0.78

Structure

x-ray diffraction · 4 distinct chains · 63% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Monopolin complex subunit CSM1	protein	149	62% helix, 17% strand	P25651
B	Monopolin complex subunit CSM1	protein	151	60% helix, 15% strand	P25651
C	Monopolin complex subunit CSM1	protein	153	61% helix, 20% strand	P25651
D	Monopolin complex subunit CSM1	protein	159	67% helix, 16% strand	P25651

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	605	0.78	0.84	62	empty
2	132	0.58	0.84	26	empty
3	148	0.54	0.81	19	empty
4	96	0.51	0.83	16	empty
5	98	0.43	0.77	14	empty

Interfaces

6 interfaces between chains.

A–B · 2347 Å² buried · 6 hydrogen bonds · protein-protein
C–D · 2259 Å² buried · 6 hydrogen bonds · protein-protein
A–C · 436 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 287 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 171 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

3N4X · Structure of Csm1 full-length · the same entry in another collection · chain C against C, TM-score 1.00
P25651 · AlphaFold monomer V2.0 prediction for monopolin complex subunit CSM1 (P25651) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25651
Elsewhere: RCSB PDB 3N4X · PDBe 3N4X · UniProt P25651

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