Research workbench

Azurin H117G, oxidized form

Analyse Azurin H117G, oxidized form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3N2J
Type: protein
Length: 1,536 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Azurin
UniProt: P00282
Ligands: CU
Pockets: 15 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J, K, L	Azurin	protein	128	15% helix, 34% strand	P00282

Ligands and binding sites

CU · Copper (II) ion · metal · 24 copies · chains A, D, B, C, E, G, F, H, I, J, L, K

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	978	0.83	0.84	124	empty
2	699	0.79	0.84	97	empty
3	955	0.76	0.79	120	empty
4	144	0.66	0.88	27	CU
5	247	0.65	0.83	39	CU

Interfaces

26 interfaces between chains.

E–G · 375 Å² buried · 3 hydrogen bonds · protein-protein
E–I · 374 Å² buried · 1 hydrogen bond · protein-protein
C–F · 351 Å² buried · 5 hydrogen bonds · protein-protein
J–L · 350 Å² buried · 2 hydrogen bonds · protein-protein
H–J · 350 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 disulfide (disulfide).

Compared structures

3N2J · Azurin H117G, oxidized form · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00282
Elsewhere: RCSB PDB 3N2J · PDBe 3N2J · UniProt P00282

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.