Research workbench
The crystal structure of a two-component sensor domain (3RD form) from pseudomonas aeruginosa PA01
Analyse The crystal structure of a two-component sensor domain (3RD form) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3N24
- Type
- protein
- Length
- 876 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensor protein
- EC
- 2.7.13.3
- UniProt
- Q9HT87
- Pockets
- 10 · best druggability 0.87
Structure
x-ray diffraction · 8 distinct chains · 86% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensor protein (EC 2.7.13.3) | protein | 109 | 83% helix, 0% strand | Q9HT87 |
| B | Sensor protein (EC 2.7.13.3) | protein | 102 | 86% helix, 0% strand | Q9HT87 |
| C | Sensor protein (EC 2.7.13.3) | protein | 123 | 85% helix, 0% strand | Q9HT87 |
| D | Sensor protein (EC 2.7.13.3) | protein | 105 | 87% helix, 0% strand | Q9HT87 |
| E | Sensor protein (EC 2.7.13.3) | protein | 102 | 90% helix, 0% strand | Q9HT87 |
| F | Sensor protein (EC 2.7.13.3) | protein | 114 | 86% helix, 0% strand | Q9HT87 |
| G | Sensor protein (EC 2.7.13.3) | protein | 110 | 84% helix, 0% strand | Q9HT87 |
| H | Sensor protein (EC 2.7.13.3) | protein | 111 | 86% helix, 0% strand | Q9HT87 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 676 | 0.87 | 0.91 | 74 | empty |
| 2 | 940 | 0.86 | 0.87 | 99 | empty |
| 3 | 107 | 0.78 | 0.97 | 19 | empty |
| 4 | 101 | 0.78 | 0.97 | 17 | empty |
| 5 | 86 | 0.77 | 0.98 | 16 | empty |
Interfaces
13 interfaces between chains.
- E–F · 2232 Ų buried · 8 hydrogen bonds · protein-protein
- G–H · 2165 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 2112 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 2038 Ų buried · 16 hydrogen bonds · protein-protein
- D–F · 793 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 modified (engineered).
Compared structures
- 3N24 · The crystal structure of a two-component sensor domain (3rd form) from Pseudomonas… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HT87
- Elsewhere: RCSB PDB 3N24 · PDBe 3N24 · UniProt Q9HT87
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