Research workbench
The crystal structure of a possible transcription regulator protein from sinorhizobium meliloti 1021
Analyse The crystal structure of a possible transcription regulator protein from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MZ1
- Type
- protein
- Length
- 836 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative transcriptional regulator
- UniProt
- Q92SG7
- Ligands
- CL
- Pockets
- 8 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative transcriptional regulator | protein | 208 | 31% helix, 34% strand | Q92SG7 |
| B, D | Putative transcriptional regulator | protein | 212 | 30% helix, 33% strand | Q92SG7 |
| C | Putative transcriptional regulator | protein | 204 | 30% helix, 35% strand | Q92SG7 |
Ligands and binding sites
- CL · Chloride ion · ion · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 659 | 0.76 | 0.81 | 60 | empty |
| 2 | 393 | 0.74 | 0.84 | 46 | empty |
| 3 | 352 | 0.70 | 0.83 | 42 | empty |
| 4 | 269 | 0.68 | 0.83 | 35 | empty |
| 5 | 308 | 0.60 | 0.78 | 38 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1484 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1378 Ų buried · 20 hydrogen bonds · protein-protein
- B–D · 332 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 28 modified (engineered).
Compared structures
- 3MZ1 · The crystal structure of a possible TRANSCRIPTION REGULATOR PROTEIN from Sinorhizobium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92SG7
- Elsewhere: RCSB PDB 3MZ1 · PDBe 3MZ1 · UniProt Q92SG7
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