Research workbench
Crystal structure of sensory box sensor histidine kinase from vibrio cholerae
Analyse Crystal structure of sensory box sensor histidine kinase from vibrio cholerae in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MXQ
- Type
- protein
- Length
- 487 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensor protein
- EC
- 2.7.13.3
- UniProt
- Q9KT21
- Pockets
- 4 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 37% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensor protein (EC 2.7.13.3) | protein | 126 | 39% helix, 31% strand | Q9KT21 |
| B | Sensor protein (EC 2.7.13.3) | protein | 119 | 34% helix, 27% strand | Q9KT21 |
| C | Sensor protein (EC 2.7.13.3) | protein | 125 | 36% helix, 31% strand | Q9KT21 |
| D | Sensor protein (EC 2.7.13.3) | protein | 117 | 38% helix, 29% strand | Q9KT21 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 588 | 0.75 | 0.82 | 69 | empty |
| 2 | 122 | 0.69 | 0.90 | 22 | empty |
| 3 | 626 | 0.66 | 0.76 | 44 | empty |
| 4 | 51 | 0.66 | 0.94 | 16 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1413 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 1367 Ų buried · 21 hydrogen bonds · protein-protein
- A–D · 580 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 548 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 153 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 3MXQ · Crystal structure of sensory box sensor histidine kinase from Vibrio cholerae · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KT21
- Elsewhere: RCSB PDB 3MXQ · PDBe 3MXQ · UniProt Q9KT21
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