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The hypoxic regulator of sterol synthesis NRO1 is a nuclear import adaptor

Analyse The hypoxic regulator of sterol synthesis NRO1 is a nuclear import adaptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3MSV
Type: protein
Length: 700 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear import adaptor, NRO1
UniProt: Q9USJ7
Pockets: 7 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclear import adaptor, NRO1	protein	352	78% helix, 0% strand	Q9USJ7
B	Nuclear import adaptor, NRO1	protein	348	78% helix, 0% strand	Q9USJ7

Pockets

7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	554	0.70	0.79	59	empty
2	69	0.59	0.89	19	empty
3	176	0.53	0.79	30	empty
4	202	0.53	0.77	32	empty
5	67	0.31	0.74	12	empty

Interfaces

1 interface between chains.

A–B · 1226 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

3MSV · The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor · the same entry in another collection · chain A against A, TM-score 1.00
Q9USJ7 · AlphaFold monomer V2.0 prediction for negative regulator of OFD1 (Q9USJ7) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9USJ7
Elsewhere: RCSB PDB 3MSV · PDBe 3MSV · UniProt Q9USJ7

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