Research workbench
Crystal structure of ectodomain of bst-2/TETHERIN/CD317 (P21)
Analyse Crystal structure of ectodomain of bst-2/TETHERIN/CD317 (P21) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MQC
- Type
- protein
- Length
- 400 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bone marrow stromal antigen 2
- UniProt
- Q10589
- Pockets
- 2 · best druggability 0.46
Structure
x-ray diffraction · 1 distinct chain · 98% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Bone marrow stromal antigen 2 | protein | 100 | 98% helix, 0% strand | Q10589 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 89 | 0.46 | 0.81 | 15 | empty |
| 2 | 76 | 0.44 | 0.81 | 16 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1794 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 1786 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 1007 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 994 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 826 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified, 2 disulfide (engineered, disulfide).
Compared structures
- 3MQC · Crystal Structure of Ectodomain of BST-2/Tetherin/CD317 (P21) · the same entry in another collection · chain D against D, TM-score 1.00
- Q10589 · AlphaFold monomer V2.0 prediction for bone marrow stromal antigen 2 (Q10589) · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q10589
- Elsewhere: RCSB PDB 3MQC · PDBe 3MQC · UniProt Q10589
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.