Research workbench
Crystal structure of ectodomain mutant of bst-2/TETHERIN/CD317 fused to mbp
Analyse Crystal structure of ectodomain mutant of bst-2/TETHERIN/CD317 fused to mbp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MQ9
- Type
- protein
- Length
- 3,632 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bone marrow stromal antigen 2 fused to maltose-binding periplasmic protein
- UniProt
- P0AEX9, Q10589
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Bone marrow stromal antigen 2 fused to maltose-binding periplasmic protein | protein | 454 | 56% helix, 17% strand | P0AEX9, Q10589 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 841 | 0.79 | 0.82 | 79 | empty |
| 2 | 833 | 0.79 | 0.82 | 76 | empty |
| 3 | 854 | 0.79 | 0.82 | 72 | empty |
| 4 | 858 | 0.78 | 0.81 | 79 | empty |
| 5 | 636 | 0.74 | 0.81 | 73 | empty |
Interfaces
19 interfaces between chains.
- A–B · 2566 Ų buried · 26 hydrogen bonds · protein-protein
- E–F · 2524 Ų buried · 25 hydrogen bonds · protein-protein
- F–H · 1544 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 1541 Ų buried · 14 hydrogen bonds · protein-protein
- B–D · 1522 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 modified (engineered).
Compared structures
- 3MQ9 · Crystal Structure of Ectodomain Mutant of BST-2/Tetherin/CD317 Fused to MBP · the same entry in another collection · chain H against H, TM-score 1.00
- Q10589 · AlphaFold monomer V2.0 prediction for bone marrow stromal antigen 2 (Q10589) · a predicted model of the same protein · chain C against A, TM-score 0.20
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEX9
- Every structure of UniProt Q10589
- Elsewhere: RCSB PDB 3MQ9 · PDBe 3MQ9 · UniProt P0AEX9 · UniProt Q10589
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