Research workbench

Crystal structure of native bovine PDP1C

Analyse Crystal structure of native bovine PDP1C in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3MQ3
Type: protein
Length: 378 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pyruvate dehydrogenase phosphatase 1
EC: 3.1.3.43
UniProt: P35816
Ligands: MN
Pockets: 6 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pyruvate dehydrogenase phosphatase 1 (EC 3.1.3.43)	protein	378	36% helix, 24% strand	P35816

Ligands and binding sites

MN · Manganese (II) ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	70	0.57	0.88	24	empty
2	133	0.50	0.79	17	empty
3	156	0.49	0.77	23	empty
4	112	0.43	0.77	24	empty
5	80	0.32	0.74	17	MN

Compared structures

3MQ3 · Crystal structure of native bovine PDP1c · the same entry in another collection · chain A against A, TM-score 1.00
P35816 · AlphaFold monomer V2.0 prediction for [pyruvate dehydrogenase… · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35816
Elsewhere: RCSB PDB 3MQ3 · PDBe 3MQ3 · UniProt P35816

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.