The structural basis for partial redundancy in a class of transcription factors, the lim-homeodomain proteins, in neural cell type specification

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 35% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 8 copies · chains A, B
• CL · Chloride ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 3MMK · The structural basis for partial redundancy in a class of transcription factors, the… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9CXV0 · AlphaFold monomer V2.0 prediction for insulin gene enhancer protein isl-2 (Q9CXV0) · a predicted model of the same protein · chain B against A, TM-score 0.53
• P53776 · AlphaFold monomer V2.0 prediction for LIM/HOMEOBOX protein LHX4 (P53776) · a predicted model of the same protein · chain B against A, TM-score 0.42

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P53776
• Every structure of UniProt Q9CXV0
• Elsewhere: RCSB PDB 3MMK · PDBe 3MMK · UniProt P53776 · UniProt Q9CXV0