Research workbench
Crystal structure of the 2009 H1N1 influenza virus hemagglutinin receptor-binding domain
Analyse Crystal structure of the 2009 H1N1 influenza virus hemagglutinin… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MLH
- Type
- protein
- Length
- 425 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hemagglutinin
- UniProt
- C4RSQ3
- Pockets
- 7 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hemagglutinin | protein | 212 | 10% helix, 37% strand | C4RSQ3 |
| B | Hemagglutinin | protein | 213 | 12% helix, 38% strand | C4RSQ3 |
Ligands and binding sites
- GOL · Glycerol · additive · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.66 | 0.78 | 63 | GOL |
| 2 | 127 | 0.45 | 0.77 | 22 | empty |
| 3 | 107 | 0.42 | 0.77 | 16 | empty |
| 4 | 70 | 0.34 | 0.76 | 16 | empty |
| 5 | 67 | 0.33 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 618 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3MLH · Crystal structure of the 2009 H1N1 influenza virus hemagglutinin receptor-binding domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C4RSQ3
- Elsewhere: RCSB PDB 3MLH · PDBe 3MLH · UniProt C4RSQ3
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