Research workbench
Crystal structure of a complex between DOK7 pH-ptb and the musk juxtamembrane region
Analyse Crystal structure of a complex between DOK7 pH-ptb and the musk juxtamembrane… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ML4
- Type
- protein
- Length
- 862 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein dok-7; Muscle, skeletal receptor tyrosine-protein kinase
- UniProt
- Q18PE0, Q61006
- Pockets
- 13 · best druggability 0.84
Structure
x-ray diffraction · 5 distinct chains · 18% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein dok-7 | protein | 205 | 19% helix, 50% strand | Q18PE0 |
| B | Protein dok-7 | protein | 207 | 18% helix, 47% strand | Q18PE0 |
| C | Protein dok-7 | protein | 208 | 19% helix, 48% strand | Q18PE0 |
| D | Protein dok-7 | protein | 206 | 17% helix, 50% strand | Q18PE0 |
| E, F, G, H | Muscle, skeletal receptor tyrosine-protein kinase | protein | 9 | 0% helix, 22% strand | Q61006 |
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 687 | 0.84 | 0.88 | 53 | empty |
| 2 | 839 | 0.73 | 0.77 | 48 | empty |
| 3 | 764 | 0.70 | 0.76 | 47 | empty |
| 4 | 408 | 0.60 | 0.76 | 48 | empty |
| 5 | 118 | 0.58 | 0.85 | 22 | empty |
Interfaces
16 interfaces between chains.
- A–B · 1053 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 1019 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 655 Ų buried · 8 hydrogen bonds · protein-protein
- C–G · 652 Ų buried · 14 hydrogen bonds · protein-protein
- B–D · 643 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 25 modified (engineered, phosphorylation).
Compared structures
- 3ML4 · Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region · the same entry in another collection · chain H against H, TM-score 1.00
- Q18PE0 · AlphaFold monomer V2.0 prediction for protein dok-7 (Q18PE0) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q18PE0
- Every structure of UniProt Q61006
- Elsewhere: RCSB PDB 3ML4 · PDBe 3ML4 · UniProt Q18PE0 · UniProt Q61006
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