Research workbench
Crystal structure of DNA-binding transcriptional dual regulator from escherichia COLI K-12
Analyse Crystal structure of DNA-binding transcriptional dual regulator from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MKL
- Type
- protein
- Length
- 215 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hth-type transcriptional regulator gadx
- UniProt
- P37639
- Pockets
- 1 · best druggability 0.24
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hth-type transcriptional regulator gadx | protein | 104 | 67% helix, 0% strand | P37639 |
| B | Hth-type transcriptional regulator gadx | protein | 111 | 66% helix, 0% strand | P37639 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.24 | 0.73 | 9 | empty |
Interfaces
1 interface between chains.
- A–B · 531 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 3MKL · Crystal structure of DNA-binding transcriptional dual regulator from Escherichia coli K-12 · the same entry in another collection · chain A against A, TM-score 1.00
- P37639 · AlphaFold monomer V2.0 prediction for hth-type transcriptional regulator gadx (P37639) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37639
- Elsewhere: RCSB PDB 3MKL · PDBe 3MKL · UniProt P37639
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