Research workbench
The crystal structure of native FG41 msad
Analyse The crystal structure of native FG41 msad in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MJZ
- Type
- protein
- Length
- 1,570 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- FG41 malonate semialdehyde decarboxylase
- EC
- 4.1.1.-
- Pockets
- 10 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, G, H, I, J, L | FG41 malonate semialdehyde decarboxylase (EC 4.1.1.-) | protein | 131 | 35% helix, 28% strand | — |
| F, K | FG41 malonate semialdehyde decarboxylase (EC 4.1.1.-) | protein | 130 | 36% helix, 28% strand | — |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.65 | 0.95 | 16 | empty |
| 2 | 476 | 0.62 | 0.76 | 71 | empty |
| 3 | 246 | 0.56 | 0.78 | 21 | empty |
| 4 | 206 | 0.54 | 0.78 | 22 | empty |
| 5 | 208 | 0.53 | 0.78 | 20 | empty |
Interfaces
17 interfaces between chains.
- A–B · 1525 Ų buried · 22 hydrogen bonds · protein-protein
- H–I · 1524 Ų buried · 23 hydrogen bonds · protein-protein
- J–L · 1521 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 1483 Ų buried · 24 hydrogen bonds · protein-protein
- E–F · 1482 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 3MJZ · The crystal structure of native FG41 MSAD · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3MJZ · PDBe 3MJZ
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