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Serendipitous crystal structure containing the heat shock transcription FACTOR'S DNA binding domain and cognate DNA that is translationally disordered

Analyse Serendipitous crystal structure containing the heat shock transcription… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1FYK
Type: protein + RNA
Length: 92 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hse DNA-phosphate backbone; Heat shock factor protein
UniProt: P22121
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Hse DNA-phosphate backbone	rna	4	—	—
A	Heat shock factor protein	protein	88	39% helix, 15% strand	P22121

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.32	0.76	11	empty

Interfaces

1 interface between chains.

C–A · 91 Å² buried · 2 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

1FYK · Serendipitous crystal structure containing the heat shock transcription FACTOR'S DNA… · the same entry in another collection · chain A against A, TM-score 1.00
P22121 · AlphaFold monomer V2.0 prediction for heat shock transcription factor (P22121) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22121
Elsewhere: RCSB PDB 1FYK · PDBe 1FYK · UniProt P22121

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