Research workbench
The structure of TL1A-DCR3 complex
Analyse The structure of TL1A-DCR3 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MI8
- Type
- protein
- Length
- 253 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor necrosis factor ligand superfamily member 15, secreted form; Tumor necrosis factor…
- UniProt
- O95150, O95407
- Pockets
- 1 · best druggability 0.54
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tumor necrosis factor ligand superfamily member 15, secreted form | protein | 144 | 2% helix, 52% strand | O95150 |
| D | Tumor necrosis factor receptor superfamily member 6B | protein | 109 | 0% helix, 39% strand | O95407 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 335 | 0.54 | 0.74 | 39 | empty |
Interfaces
1 interface between chains.
- A–D · 438 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 3MI8 · The structure of TL1A-DCR3 COMPLEX · the same entry in another collection · chain A against A, TM-score 1.00
- O95150 · AlphaFold monomer V2.0 prediction for tumor necrosis factor ligand superfamily member 15… · a predicted model of the same protein · chain A against A, TM-score 0.96
- O95407 · AlphaFold monomer V2.0 prediction for tumor necrosis factor receptor superfamily member… · a predicted model of the same protein · chain D against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95150
- Every structure of UniProt O95407
- Elsewhere: RCSB PDB 3MI8 · PDBe 3MI8 · UniProt O95150 · UniProt O95407
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