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Crystal structure of methyl transferase from methanosarcina mazei

Analyse Crystal structure of methyl transferase from methanosarcina mazei in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3MGG
Type: protein
Length: 499 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methyltransferase
EC: 2.1.1.-
UniProt: Q8PVL4
Pockets: 5 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methyltransferase (EC 2.1.1.-)	protein	246	46% helix, 25% strand	Q8PVL4
B	Methyltransferase (EC 2.1.1.-)	protein	253	45% helix, 25% strand	Q8PVL4

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	459	0.66	0.78	48	empty
2	317	0.59	0.77	30	empty
3	160	0.47	0.76	32	empty
4	98	0.39	0.76	19	empty
5	50	0.25	0.72	15	empty

Interfaces

1 interface between chains.

A–B · 1153 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

3MGG · Crystal Structure of Methyl Transferase from Methanosarcina mazei · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8PVL4
Elsewhere: RCSB PDB 3MGG · PDBe 3MGG · UniProt Q8PVL4

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