Research workbench
Crystal structure of the orange carotenoid protein R155L mutant from cyanobacteria synechocystis sp. pcc 6803
Analyse Crystal structure of the orange carotenoid protein R155L mutant from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MG3
- Type
- protein
- Length
- 608 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Orange carotenoid-binding protein
- UniProt
- P74102
- Ligands
- ECH
- Pockets
- 9 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Orange carotenoid-binding protein | protein | 304 | 48% helix, 18% strand | P74102 |
| B | Orange carotenoid-binding protein | protein | 304 | 47% helix, 18% strand | P74102 |
Ligands and binding sites
- ECH · beta,beta-caroten-4-one · ligand · 2 copies · chains A, B
- GOL · Glycerol · additive · 7 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 624 | 0.86 | 0.90 | 63 | ECH, GOL |
| 2 | 746 | 0.86 | 0.89 | 76 | ECH, GOL |
| 3 | 119 | 0.77 | 0.97 | 25 | GOL |
| 4 | 117 | 0.75 | 0.95 | 25 | empty |
| 5 | 288 | 0.59 | 0.78 | 38 | empty |
Interfaces
1 interface between chains.
- A–B · 1179 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 3MG3 · Crystal structure of the orange carotenoid protein R155L mutant from cyanobacteria… · the same entry in another collection · chain A against A, TM-score 1.00
- P74102 · AlphaFold monomer V2.0 prediction for orange carotenoid-binding protein (P74102) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P74102
- Elsewhere: RCSB PDB 3MG3 · PDBe 3MG3 · UniProt P74102
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