Research workbench
Crystal structure of anti-beta-amyloid antibody C705
Analyse Crystal structure of anti-beta-amyloid antibody C705 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MCK
- Type
- protein
- Length
- 890 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- C705 monoclonal light chain; C705 monoclonal heavy chain
- Pockets
- 13 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, A | C705 monoclonal light chain | protein | 219 | 6% helix, 50% strand | — |
| H, B | C705 monoclonal heavy chain | protein | 226 | 5% helix, 49% strand | — |
Ligands and binding sites
- ACT · Acetate ion · additive · 2 copies · chains L, H, A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 403 | 0.58 | 0.75 | 55 | empty |
| 2 | 397 | 0.56 | 0.74 | 56 | empty |
| 3 | 145 | 0.50 | 0.79 | 24 | empty |
| 4 | 152 | 0.46 | 0.76 | 24 | empty |
| 5 | 109 | 0.45 | 0.79 | 24 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1927 Ų buried · 21 hydrogen bonds · protein-protein
- L–H · 1874 Ų buried · 20 hydrogen bonds · protein-protein
- L–A · 473 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 3MCK · Crystal structure of anti-beta-amyloid antibody C705 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3MCK · PDBe 3MCK
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