Research workbench
Structure of the DOM34-HBS1 complex and implications for its role in no-go decay
Analyse Structure of the DOM34-HBS1 complex and implications for its role in no-go decay in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MCA
- Type
- protein
- Length
- 718 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongation factor 1 alpha-like protein; Protein DOM34
- EC
- 3.1.-.-
- UniProt
- O74774, Q9USL5
- Pockets
- 15 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Elongation factor 1 alpha-like protein | protein | 377 | 18% helix, 37% strand | O74774 |
| B | Protein DOM34 (EC 3.1.-.-) | protein | 341 | 36% helix, 20% strand | Q9USL5 |
Pockets
15 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 272 | 0.68 | 0.83 | 28 | empty |
| 2 | 438 | 0.67 | 0.79 | 61 | empty |
| 3 | 376 | 0.65 | 0.79 | 39 | empty |
| 4 | 52 | 0.63 | 0.93 | 16 | empty |
| 5 | 58 | 0.57 | 0.90 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1226 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 3MCA · Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay · the same entry in another collection · chain A against A, TM-score 1.00
- Q9USL5 · AlphaFold monomer V2.0 prediction for protein DOM34 (Q9USL5) · a predicted model of the same protein · chain B against A, TM-score 0.95
- O74774 · AlphaFold monomer V2.0 prediction for elongation factor 1 alpha-like protein (O74774) · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O74774
- Every structure of UniProt Q9USL5
- Elsewhere: RCSB PDB 3MCA · PDBe 3MCA · UniProt O74774 · UniProt Q9USL5
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