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The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). tmp complex.
Analyse The structural basis of the catalytic mechanism and regulation of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FXO
- Type
- protein
- Length
- 2,340 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose-1-phosphate thymidylyltransferase
- EC
- 2.7.7.24
- UniProt
- Q9HU22
- Ligands
- TMP, SO4
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, H | Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) | protein | 292 | 38% helix, 23% strand | Q9HU22 |
| B, E, F, G | Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) | protein | 293 | 38% helix, 23% strand | Q9HU22 |
Ligands and binding sites
- TMP · Thymidine-5'-phosphate · ligand · 16 copies · chains A, C, B, D, E, H, F, G
- SO4 · Sulfate ion · ion · 13 copies · chains A, C, D, B, E, F, G, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 600 | 0.80 | 0.85 | 67 | TMP |
| 2 | 81 | 0.78 | 0.99 | 17 | empty |
| 3 | 74 | 0.77 | 0.99 | 17 | empty |
| 4 | 77 | 0.76 | 0.98 | 16 | empty |
| 5 | 601 | 0.76 | 0.82 | 63 | TMP, SO4 |
Interfaces
13 interfaces between chains.
- A–C · 2005 Ų buried · 49 hydrogen bonds · protein-protein
- E–H · 2004 Ų buried · 44 hydrogen bonds · protein-protein
- F–G · 1992 Ų buried · 44 hydrogen bonds · protein-protein
- B–D · 1991 Ų buried · 45 hydrogen bonds · protein-protein
- G–H · 1331 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 1FXO · The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HU22
- Elsewhere: RCSB PDB 1FXO · PDBe 1FXO · UniProt Q9HU22
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