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Crystal structure of the amino terminal coiled coil domain of the mycobacterium tuberculosis proteasomal ATPase mpa

Analyse Crystal structure of the amino terminal coiled coil domain of the mycobacterium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3M9H
Type: protein
Length: 258 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proteasome-associated ATPase
UniProt: P63345
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 93% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Proteasome-associated ATPase	protein	43	93% helix, 0% strand	P63345

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.72	0.98	14	empty
2	73	0.31	0.74	15	empty

Interfaces

11 interfaces between chains.

B–D · 1194 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 1166 Å² buried · 10 hydrogen bonds · protein-protein
B–C · 1020 Å² buried · 7 hydrogen bonds · protein-protein
A–D · 1007 Å² buried · 7 hydrogen bonds · protein-protein
C–F · 298 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

3M9H · Crystal structure of the amino terminal coiled coil domain of the Mycobacterium… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63345
Elsewhere: RCSB PDB 3M9H · PDBe 3M9H · UniProt P63345

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