Research workbench
Crystal structure of the membrane domain of respiratory complex I from escherichia COLI
Analyse Crystal structure of the membrane domain of respiratory complex I from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3M9C
- Type
- protein
- Length
- 1,524 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NADH-quinone oxidoreductase subunit nuol; NADH-quinone oxidoreductase subunit nuom…
- EC
- 1.6.5.3
- Pockets
- 9 · best druggability 0.65
Structure
x-ray diffraction · 4 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | NADH-quinone oxidoreductase subunit nuol (EC 1.6.5.3) | protein | 474 | 0% helix, 0% strand | — |
| M | NADH-quinone oxidoreductase subunit nuom (EC 1.6.5.3) | protein | 391 | 0% helix, 0% strand | — |
| N | NADH-quinone oxidoreductase subunit nuon (EC 1.6.5.3) | protein | 378 | 0% helix, 0% strand | — |
| R | NADH-quinone oxidoreductase subunits NUOA,J and K (EC 1.6.5.3) | protein | 281 | 0% helix, 0% strand | — |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 551 | 0.65 | 0.76 | 113 | empty |
| 2 | 606 | 0.60 | 0.73 | 106 | empty |
| 3 | 426 | 0.55 | 0.73 | 77 | empty |
| 4 | 353 | 0.51 | 0.72 | 70 | empty |
| 5 | 203 | 0.42 | 0.72 | 44 | empty |
Interfaces
5 interfaces between chains.
- N–R · 200 Ų buried · 0 hydrogen bonds · protein-protein
- L–M · 170 Ų buried · 0 hydrogen bonds · protein-protein
- L–N · 63 Ų buried · 0 hydrogen bonds · protein-protein
- M–N · 52 Ų buried · 0 hydrogen bonds · protein-protein
- L–R · 25 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3M9C · Crystal structure of the membrane domain of respiratory complex I from Escherichia coli · the same entry in another collection · chain M against M, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3M9C · PDBe 3M9C
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