Research workbench
Crystal structure of archaeal prefoldin (gimc).
Analyse Crystal structure of archaeal prefoldin (gimc). in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FXK
- Type
- protein
- Length
- 349 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prefoldin; Protein (prefoldin)
- UniProt
- O26774, O27646
- Pockets
- 3 · best druggability 0.33
Structure
x-ray diffraction · 3 distinct chains · 73% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Prefoldin | protein | 107 | 77% helix, 9% strand | O26774 |
| B | Prefoldin | protein | 109 | 76% helix, 9% strand | O26774 |
| C | Protein (prefoldin) | protein | 133 | 67% helix, 20% strand | O27646 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.33 | 0.72 | 18 | empty |
| 2 | 77 | 0.30 | 0.73 | 13 | empty |
| 3 | 53 | 0.29 | 0.75 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–C · 655 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 554 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 1FXK · Crystal structure of archaeal prefoldin (gimc). · the same entry in another collection · chain A against A, TM-score 1.00
- O27646 · AlphaFold monomer V2.0 prediction for prefoldin subunit alpha (O27646) · a predicted model of the same protein · chain C against A, TM-score 0.99
- O26774 · AlphaFold monomer V2.0 prediction for prefoldin subunit beta (O26774) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O26774
- Every structure of UniProt O27646
- Elsewhere: RCSB PDB 1FXK · PDBe 1FXK · UniProt O26774 · UniProt O27646
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