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Entamoeba histolytica asparaginyl-tRNA synthetase (asnrs)

Analyse Entamoeba histolytica asparaginyl-tRNA synthetase (asnrs) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3M4Q
Type: protein
Length: 866 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Asparaginyl-tRNA synthetase, putative
EC: 6.1.1.22
UniProt: C4LWW8
Pockets: 8 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Asparaginyl-tRNA synthetase, putative (EC 6.1.1.22)	protein	429	33% helix, 29% strand	C4LWW8
B	Asparaginyl-tRNA synthetase, putative (EC 6.1.1.22)	protein	437	31% helix, 28% strand	C4LWW8

Pockets

8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	694	0.75	0.81	76	empty
2	72	0.73	0.97	30	empty
3	572	0.67	0.77	68	empty
4	426	0.65	0.78	41	empty
5	405	0.63	0.77	46	empty

Interfaces

1 interface between chains.

A–B · 4052 Å² buried · 76 hydrogen bonds · protein-protein

Compared structures

3M4Q · Entamoeba histolytica asparaginyl-tRNA synthetase (AsnRS) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C4LWW8
Elsewhere: RCSB PDB 3M4Q · PDBe 3M4Q · UniProt C4LWW8

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