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SARS-cov main protease triple mutant STI/A with two N-terminal additional residue (gly-ser)

Analyse SARS-cov main protease triple mutant STI/A with two N-terminal additional… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3M3V
Type: protein
Length: 610 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C-like proteinase
EC: 3.4.22.-
UniProt: P0C6U8
Pockets: 7 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3C-like proteinase (EC 3.4.22.-)	protein	306	25% helix, 28% strand	P0C6U8
B	3C-like proteinase (EC 3.4.22.-)	protein	304	28% helix, 26% strand	P0C6U8

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1081	0.78	0.80	84	empty
2	747	0.69	0.76	85	empty
3	132	0.45	0.77	28	empty
4	92	0.34	0.74	18	empty
5	79	0.32	0.74	20	empty

Interfaces

1 interface between chains.

A–B · 1457 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

3M3V · SARS-CoV main protease triple mutant STI/A with two N-terminal additional residue… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0C6U8
Elsewhere: RCSB PDB 3M3V · PDBe 3M3V · UniProt P0C6U8

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