Research workbench
Hypothetical protein from leishmania major
Analyse Hypothetical protein from leishmania major in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3M3I
- Type
- protein
- Length
- 1,418 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative uncharacterized protein
- UniProt
- Q4FX13
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 17% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, H | Putative uncharacterized protein | protein | 177 | 17% helix, 41% strand | Q4FX13 |
| B | Putative uncharacterized protein | protein | 177 | 17% helix, 41% strand | Q4FX13 |
| C, D | Putative uncharacterized protein | protein | 179 | 17% helix, 41% strand | Q4FX13 |
| F, G | Putative uncharacterized protein | protein | 176 | 16% helix, 41% strand | Q4FX13 |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1161 | 0.77 | 0.79 | 80 | empty |
| 2 | 1194 | 0.77 | 0.79 | 80 | empty |
| 3 | 191 | 0.65 | 0.85 | 39 | empty |
| 4 | 79 | 0.64 | 0.91 | 23 | empty |
| 5 | 100 | 0.61 | 0.88 | 29 | empty |
Interfaces
12 interfaces between chains.
- D–G · 1505 Ų buried · 19 hydrogen bonds · protein-protein
- B–E · 1502 Ų buried · 15 hydrogen bonds · protein-protein
- A–H · 1498 Ų buried · 15 hydrogen bonds · protein-protein
- C–F · 1493 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 406 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3M3I · Hypothetical protein from Leishmania major · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4FX13
- Elsewhere: RCSB PDB 3M3I · PDBe 3M3I · UniProt Q4FX13
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