Research workbench
Guinea pig 11BETA hydroxysteroid dehydrogenase with pf-877423
Analyse Guinea pig 11BETA hydroxysteroid dehydrogenase with pf-877423 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LZ6
- Type
- protein
- Length
- 1,052 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Corticosteroid 11-beta-dehydrogenase isozyme 1
- EC
- 1.1.1.146
- UniProt
- Q6QLL4
- Ligands
- NAP, A0D
- Pockets
- 13 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) | protein | 263 | 52% helix, 16% strand | Q6QLL4 |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 4 copies · chains A, B, C, D
- A0D · N-adamantan-2-yl-1-ethyl-D-prolinamide · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 680 | 0.84 | 0.88 | 61 | NAP, A0D |
| 2 | 749 | 0.83 | 0.87 | 72 | NAP, A0D |
| 3 | 709 | 0.83 | 0.87 | 72 | NAP, A0D |
| 4 | 732 | 0.83 | 0.86 | 73 | NAP, A0D |
| 5 | 254 | 0.73 | 0.87 | 33 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2777 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 2759 Ų buried · 26 hydrogen bonds · protein-protein
- A–D · 473 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 397 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 222 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3LZ6 · Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423 · the same entry in another collection · chain D against D, TM-score 1.00
- Q6QLL4 · AlphaFold monomer V2.0 prediction for corticosteroid 11-beta- dehydrogenase isozyme 1… · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6QLL4
- Elsewhere: RCSB PDB 3LZ6 · PDBe 3LZ6 · UniProt Q6QLL4
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