Research workbench

Crystal structure of the yeast SAC1: implications for its phosphoinositide phosphatase function

Analyse Crystal structure of the yeast SAC1: implications for its phosphoinositide… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3LWT
Type: protein
Length: 457 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoinositide phosphatase SAC1
EC: 3.1.3.-
UniProt: P32368
Pockets: 7 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Phosphoinositide phosphatase SAC1 (EC 3.1.3.-)	protein	457	30% helix, 30% strand	P32368

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	479	0.61	0.75	63	empty
2	60	0.55	0.89	19	empty
3	101	0.49	0.81	24	empty
4	63	0.44	0.82	20	empty
5	57	0.42	0.82	19	empty

Compared structures

3LWT · Crystal structure of the Yeast Sac1: Implications for its phosphoinositide phosphatase… · the same entry in another collection · chain X against X, TM-score 1.00
P32368 · AlphaFold monomer V2.0 prediction for phosphatidylinositol-3-phosphatase SAC1 (P32368) · a predicted model of the same protein · chain X against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P32368
Elsewhere: RCSB PDB 3LWT · PDBe 3LWT · UniProt P32368

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.