Research workbench
Crystal structure of E.COLI iscs-tusa complex (form 2)
Analyse Crystal structure of E.COLI iscs-tusa complex (form 2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LVK
- Type
- protein
- Length
- 464 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine desulfurase; Sulfurtransferase tusa
- EC
- 2.8.1.7, 2.8.1.-
- UniProt
- P0A6B9, P0A892
- Ligands
- PLP
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine desulfurase (EC 2.8.1.7) | protein | 388 | 41% helix, 16% strand | P0A6B9 |
| B | Sulfurtransferase tusa (EC 2.8.1.-) | protein | 76 | 29% helix, 29% strand | P0A892 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.58 | 0.82 | 22 | empty |
| 2 | 88 | 0.43 | 0.79 | 19 | empty |
| 3 | 71 | 0.27 | 0.72 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 746 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 3LVK · Crystal Structure of E.coli IscS-TusA complex (form 2) · the same entry in another collection · chain A against A, TM-score 1.00
- P0A6B9 · AlphaFold monomer V2.0 prediction for cysteine desulfurase iscs (P0A6B9) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P0A892 · AlphaFold monomer V2.0 prediction for sulfur carrier protein tusa (P0A892) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6B9
- Every structure of UniProt P0A892
- Elsewhere: RCSB PDB 3LVK · PDBe 3LVK · UniProt P0A6B9 · UniProt P0A892
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