Research workbench
Crystal structure of the drosophila epidermal growth factor receptor ectodomain complexed with a low affinity spitz mutant
Analyse Crystal structure of the drosophila epidermal growth factor receptor ectodomain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LTG
- Type
- protein
- Length
- 1,104 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epidermal growth factor receptor; Protein spitz
- EC
- 2.7.10.-
- UniProt
- P04412, Q01083
- Pockets
- 17 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 11% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Epidermal growth factor receptor (EC 2.7.10.-) | protein | 522 | 11% helix, 27% strand | P04412 |
| C | Epidermal growth factor receptor (EC 2.7.10.-) | protein | 531 | 11% helix, 27% strand | P04412 |
| D | Protein spitz | protein | 51 | 12% helix, 39% strand | Q01083 |
Pockets
17 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 543 | 0.77 | 0.84 | 63 | empty |
| 2 | 346 | 0.71 | 0.84 | 44 | empty |
| 3 | 577 | 0.67 | 0.77 | 54 | empty |
| 4 | 138 | 0.52 | 0.80 | 21 | empty |
| 5 | 241 | 0.51 | 0.76 | 31 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1760 Ų buried · 31 hydrogen bonds · protein-protein
- C–D · 1588 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 44 disulfide (disulfide).
Compared structures
- 3LTG · Crystal structure of the Drosophila Epidermal Growth Factor Receptor ectodomain complexed… · the same entry in another collection · chain A against A, TM-score 1.00
- Q01083 · AlphaFold monomer V2.0 prediction for protein spitz (Q01083) · a predicted model of the same protein · chain D against A, TM-score 0.96
- P04412 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P04412) · a predicted model of the same protein · chain A against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04412
- Every structure of UniProt Q01083
- Elsewhere: RCSB PDB 3LTG · PDBe 3LTG · UniProt P04412 · UniProt Q01083
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