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Anti-tetrahydrocannabinol Fab fragment, free form

Analyse Anti-tetrahydrocannabinol Fab fragment, free form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3LS5
Type: protein
Length: 434 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Light chain of antibody Fab fragment; Heavy chain of antibody Fab fragment
Pockets: 5 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Light chain of antibody Fab fragment	protein	215	7% helix, 53% strand	—
H	Heavy chain of antibody Fab fragment	protein	219	5% helix, 50% strand	—

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	281	0.58	0.78	44	empty
2	364	0.58	0.75	45	empty
3	132	0.56	0.82	27	empty
4	81	0.32	0.74	16	empty
5	63	0.30	0.74	16	empty

Interfaces

1 interface between chains.

L–H · 1915 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

3LS5 · Anti-tetrahydrocannabinol Fab Fragment, Free Form · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3LS5 · PDBe 3LS5

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