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Structure of E. COLI adic (P1)

Analyse Structure of E. COLI adic (P1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3LRC
Type: protein
Length: 1,640 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ARGININE/AGMATINE antiporter
UniProt: P60063
Pockets: 20 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 60% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	ARGININE/AGMATINE antiporter	protein	410	60% helix, 0% strand	P60063

Pockets

20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	332	0.82	0.92	46	empty
2	398	0.81	0.90	52	empty
3	384	0.81	0.90	53	empty
4	384	0.81	0.89	55	empty
5	806	0.75	0.79	122	empty

Interfaces

3 interfaces between chains.

A–B · 2152 Å² buried · 11 hydrogen bonds · protein-protein
C–D · 2120 Å² buried · 7 hydrogen bonds · protein-protein
B–C · 172 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

3LRC · Structure of E. coli AdiC (P1) · the same entry in another collection · chain D against D, TM-score 1.00
P60063 · AlphaFold monomer V2.0 prediction for ARGININE/AGMATINE antiporter (P60063) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P60063
Elsewhere: RCSB PDB 3LRC · PDBe 3LRC · UniProt P60063

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