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Crystal structure of 2-succinyl-6-hydroxy-2,4-cyclohexadiene 1- carboxylic acid SYNTHASE/2-oxoglutarate decarboxylase from listeria monocytogenes str. 4B F2365
Analyse Crystal structure of 2-succinyl-6-hydroxy-2,4-cyclohexadiene 1- carboxylic acid… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LQ1
- Type
- protein
- Length
- 1,031 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase
- EC
- 2.2.1.9
- UniProt
- Q71YZ2
- Pockets
- 6 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase (EC 2.2.1.9) | protein | 513 | 42% helix, 18% strand | Q71YZ2 |
| B | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase (EC 2.2.1.9) | protein | 518 | 41% helix, 18% strand | Q71YZ2 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 916 | 0.80 | 0.82 | 94 | empty |
| 2 | 906 | 0.78 | 0.81 | 86 | empty |
| 3 | 1013 | 0.75 | 0.78 | 74 | empty |
| 4 | 61 | 0.41 | 0.81 | 16 | empty |
| 5 | 69 | 0.34 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1755 Ų buried · 31 hydrogen bonds · protein-protein
Compared structures
- 3LQ1 · Crystal structure of 2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylic acid… · the same entry in another collection · chain A against A, TM-score 1.00
- Q71YZ2 · AlphaFold monomer V2.0 prediction for 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-c… · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q71YZ2
- Elsewhere: RCSB PDB 3LQ1 · PDBe 3LQ1 · UniProt Q71YZ2
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