Research workbench
Atomic model of mm-cpn in the closed state
Analyse Atomic model of mm-cpn in the closed state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LOS
- Type
- protein
- Length
- 8,512 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chaperonin
- UniProt
- Q877G8
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 1 distinct chain · 38% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | Chaperonin | protein | 532 | 38% helix, 2% strand | Q877G8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 698 | 0.89 | 0.93 | 111 | empty |
| 2 | 651 | 0.88 | 0.93 | 120 | empty |
| 3 | 913 | 0.88 | 0.90 | 136 | empty |
| 4 | 903 | 0.88 | 0.90 | 141 | empty |
| 5 | 1010 | 0.87 | 0.88 | 138 | empty |
Interfaces
56 interfaces between chains.
- G–H · 3013 Ų buried · 42 hydrogen bonds · protein-protein
- K–L · 3012 Ų buried · 42 hydrogen bonds · protein-protein
- M–N · 3012 Ų buried · 42 hydrogen bonds · protein-protein
- A–B · 3011 Ų buried · 42 hydrogen bonds · protein-protein
- A–H · 3007 Ų buried · 43 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 disulfide (disulfide).
Compared structures
- 3LOS · Atomic Model of Mm-cpn in the Closed State · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q877G8
- Elsewhere: RCSB PDB 3LOS · PDBe 3LOS · UniProt Q877G8
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