Research workbench

Crystal structure of pbpa from mycobacterium tuberculosis

Analyse Crystal structure of pbpa from mycobacterium tuberculosis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3LO7
Type: protein
Length: 803 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Penicillin-binding protein a
EC: 3.4.16.4
UniProt: P71586
Pockets: 9 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Penicillin-binding protein a (EC 3.4.16.4)	protein	420	34% helix, 21% strand	P71586
B	Penicillin-binding protein a (EC 3.4.16.4)	protein	383	36% helix, 19% strand	P71586

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.65	0.95	20	empty
2	123	0.60	0.86	25	empty
3	258	0.57	0.78	36	empty
4	272	0.53	0.76	39	empty
5	157	0.48	0.77	33	empty

Interfaces

1 interface between chains.

A–B · 833 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3LO7 · Crystal structure of PBPA from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P71586
Elsewhere: RCSB PDB 3LO7 · PDBe 3LO7 · UniProt P71586

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.