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Crystal structure of E.COLI ybcl, a new member of the mammalian pebp family

Analyse Crystal structure of E.COLI ybcl, a new member of the mammalian pebp family in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1FUX
Type
protein
Length
329 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Hypothetical 19.5 kda protein in emre-rus intergenic region
UniProt
P77368
Pockets
2 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 33% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AHypothetical 19.5 kda protein in emre-rus intergenic regionprotein1657% helix, 33% strandP77368
BHypothetical 19.5 kda protein in emre-rus intergenic regionprotein1649% helix, 34% strandP77368

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1940.560.8521empty
2680.520.8621empty

Interfaces

1 interface between chains.

  • A–B · 838 Ų buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide, 2 modified (disulfide, engineered).

Compared structures

  • 1FUX · Crystal structure of E.COLI ybcl, a new member of the mammalian pebp family · the same entry in another collection · chain A against A, TM-score 1.00
  • P77368 · AlphaFold monomer V2.0 prediction for UPF0098 protein ybcl (P77368) · a predicted model of the same protein · chain B against A, TM-score 0.99

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