Research workbench
Crystal structure of mouse VPS26B(L197S/R199E) in spacegroup P41 21 2
Analyse Crystal structure of mouse VPS26B(L197S/R199E) in spacegroup P41 21 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LH9
- Type
- protein
- Length
- 574 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vacuolar protein sorting-associated protein 26B
- UniProt
- Q8C0E2
- Pockets
- 10 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 62% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vacuolar protein sorting-associated protein 26B | protein | 286 | 2% helix, 63% strand | Q8C0E2 |
| B | Vacuolar protein sorting-associated protein 26B | protein | 288 | 2% helix, 61% strand | Q8C0E2 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 462 | 0.63 | 0.77 | 55 | empty |
| 2 | 379 | 0.60 | 0.77 | 41 | empty |
| 3 | 170 | 0.52 | 0.79 | 36 | empty |
| 4 | 182 | 0.50 | 0.77 | 35 | empty |
| 5 | 112 | 0.40 | 0.76 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1096 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 3LH9 · Crystal structure of mouse VPS26B(L197S/R199E) in spacegroup P41 21 2 · the same entry in another collection · chain B against B, TM-score 1.00
- Q8C0E2 · AlphaFold monomer V2.0 prediction for vacuolar protein sorting- associated protein 26B… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8C0E2
- Elsewhere: RCSB PDB 3LH9 · PDBe 3LH9 · UniProt Q8C0E2
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