Research workbench
Crystal structure of manxa from thermoanaerobacter tengcongensis
Analyse Crystal structure of manxa from thermoanaerobacter tengcongensis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LFH
- Type
- protein
- Length
- 802 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphotransferase system, MANNOSE/FRUCTOSE-specific component iia
- UniProt
- Q8RD55
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 6 distinct chains · 50% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphotransferase system, MANNOSE/FRUCTOSE-specific component iia | protein | 129 | 50% helix, 19% strand | Q8RD55 |
| B | Phosphotransferase system, MANNOSE/FRUCTOSE-specific component iia | protein | 144 | 51% helix, 19% strand | Q8RD55 |
| C | Phosphotransferase system, MANNOSE/FRUCTOSE-specific component iia | protein | 134 | 51% helix, 19% strand | Q8RD55 |
| D | Phosphotransferase system, MANNOSE/FRUCTOSE-specific component iia | protein | 128 | 51% helix, 19% strand | Q8RD55 |
| E | Phosphotransferase system, MANNOSE/FRUCTOSE-specific component iia | protein | 138 | 50% helix, 19% strand | Q8RD55 |
| F | Phosphotransferase system, MANNOSE/FRUCTOSE-specific component iia | protein | 129 | 49% helix, 20% strand | Q8RD55 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 795 | 0.77 | 0.81 | 77 | empty |
| 2 | 705 | 0.71 | 0.78 | 72 | empty |
| 3 | 129 | 0.50 | 0.80 | 19 | empty |
Interfaces
11 interfaces between chains.
- A–B · 1723 Ų buried · 23 hydrogen bonds · protein-protein
- E–F · 1669 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 1633 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 517 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 204 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3LFH · Crystal structure of manxA from Thermoanaerobacter tengcongensis · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8RD55
- Elsewhere: RCSB PDB 3LFH · PDBe 3LFH · UniProt Q8RD55
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