Research workbench
Structure of TOM71 complexed with HSP70 SSA1 C terminal tail indicating conformational plasticity
Analyse Structure of TOM71 complexed with HSP70 SSA1 C terminal tail indicating… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LCA
- Type
- protein
- Length
- 486 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein TOM71; Heat shock protein SSA1
- UniProt
- P38825, P10591
- Pockets
- 7 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein TOM71 | protein | 482 | 79% helix, 0% strand | P38825 |
| Q | Heat shock protein SSA1 | protein | 4 | 0% helix, 0% strand | P10591 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 479 | 0.61 | 0.75 | 55 | GOL |
| 2 | 175 | 0.55 | 0.80 | 22 | empty |
| 3 | 118 | 0.44 | 0.77 | 19 | empty |
| 4 | 107 | 0.43 | 0.77 | 15 | empty |
| 5 | 155 | 0.41 | 0.73 | 27 | empty |
Interfaces
1 interface between chains.
- A–Q · 321 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3LCA · Structure of Tom71 complexed with Hsp70 Ssa1 C terminal tail indicating conformational… · the same entry in another collection · chain A against A, TM-score 1.00
- P10591 · AlphaFold monomer V2.0 prediction for heat shock protein SSA1 (P10591) · a predicted model of the same protein · chain Q against A, TM-score 0.99
- P38825 · AlphaFold monomer V2.0 prediction for protein TOM71 (P38825) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38825
- Every structure of UniProt P10591
- Elsewhere: RCSB PDB 3LCA · PDBe 3LCA · UniProt P38825 · UniProt P10591
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