Research workbench
Alpha-helical barrel formed by the decamer of the zinc resistance- associated protein (STM4172) from salmonella enterica subsp. enterica serovar typhimurium str. LT2
Analyse Alpha-helical barrel formed by the decamer of the zinc resistance- associated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LAY
- Type
- protein
- Length
- 787 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Zinc resistance-associated protein
- UniProt
- Q9L9I0
- Pockets
- 16 · best druggability 0.56
Structure
x-ray diffraction · 6 distinct chains · 84% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Zinc resistance-associated protein | protein | 79 | 85% helix, 0% strand | Q9L9I0 |
| D, E | Zinc resistance-associated protein | protein | 78 | 83% helix, 0% strand | Q9L9I0 |
| F, I | Zinc resistance-associated protein | protein | 78 | 86% helix, 0% strand | Q9L9I0 |
| G | Zinc resistance-associated protein | protein | 77 | 81% helix, 0% strand | Q9L9I0 |
| H | Zinc resistance-associated protein | protein | 80 | 84% helix, 0% strand | Q9L9I0 |
| J | Zinc resistance-associated protein | protein | 81 | 84% helix, 0% strand | Q9L9I0 |
Pockets
16 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 302 | 0.56 | 0.76 | 33 | empty |
| 2 | 310 | 0.56 | 0.76 | 37 | empty |
| 3 | 294 | 0.55 | 0.76 | 33 | empty |
| 4 | 291 | 0.55 | 0.76 | 34 | empty |
| 5 | 237 | 0.49 | 0.74 | 30 | empty |
Interfaces
19 interfaces between chains.
- A–B · 740 Ų buried · 7 hydrogen bonds · protein-protein
- I–J · 722 Ų buried · 3 hydrogen bonds · protein-protein
- E–F · 711 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 676 Ų buried · 3 hydrogen bonds · protein-protein
- G–H · 673 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3LAY · Alpha-Helical barrel formed by the decamer of the zinc resistance-associated protein… · the same entry in another collection · chain J against J, TM-score 1.00
- Q9L9I0 · AlphaFold monomer V2.0 prediction for zinc resistance-associated protein (Q9L9I0) · a predicted model of the same protein · chain F against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9L9I0
- Elsewhere: RCSB PDB 3LAY · PDBe 3LAY · UniProt Q9L9I0
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