Research workbench
Crystal structure of ntca in complex with 2-oxoglutarate
Analyse Crystal structure of ntca in complex with 2-oxoglutarate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3LA2
- Type
- protein
- Length
- 392 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Global nitrogen regulator
- UniProt
- P0A4U6
- Ligands
- AKG
- Pockets
- 7 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Global nitrogen regulator | protein | 196 | 43% helix, 29% strand | P0A4U6 |
Ligands and binding sites
- AKG · 2-oxoglutaric acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.70 | 0.98 | 18 | empty |
| 2 | 58 | 0.69 | 0.96 | 18 | empty |
| 3 | 161 | 0.42 | 0.74 | 30 | empty |
| 4 | 148 | 0.39 | 0.73 | 27 | empty |
| 5 | 87 | 0.37 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2021 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A4U6
- Elsewhere: RCSB PDB 3LA2 · PDBe 3LA2 · UniProt P0A4U6
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